While weakened bones and fatigue may not sound like a good combination with exercise, staying active will keep your joints and bones strong, and prevent the bone malformation associated with Paget’s disease. Paget’s disease can also be caused by a long-term infection, and exercise is a good way to boost your immune system and metabolism to prevent this from manifesting. Finally, exercise will prevent a sedentary lifestyle, which can increase associated symptoms of Paget’s disease, such as arthritis and osteoporosis.