When you are suffering from the painful and often embarrassing condition of anal itching, one of the best remedies that you can topically apply is petroleum jelly. Anal itching can be caused by everything from poor hygiene and itchy undergarment material to yeast infections or anal tumors, but the condition is always exacerbated by excess friction. Petroleum jelly can create a barrier between your skin and other possible irritants, even the other cheek of your buttocks. When anal itching flares up, apply a thin layer of petroleum jelly and you can experience almost immediate relief from irritation.