Chronic Fatigue Syndrome would be bad enough, but sufferers also have to contend with the many psychological side effects of the condition, such as depression, mood swings and hopelessness. One of the best methods to counter both the physical and mental side effects of Chronic Fatigue Syndrome is the use of St. John’s Wort. This world-famous herb is also prescribed as a sleep aid if insomnia and restless sleep are part of your symptoms. Finally, this herb has certain antiviral and antibacterial effects, which can protect your immune system from any further infections, which can leave you even weaker!