Research Warns Of Early False Negative In COVID Tests

by Paromita Datta published on -

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Early testing for COVID-19 may not show accurate results. Research by John Hopkins School of Medicine, published in the Annals of Internal Medicine found that early testing for the presence of SARS-CoV-2 is likely to give us a false negative even when the patient may be infected. SARS-COV-2 is the virus that causes COVID-19.

Doctor and nurse wearing PPE, checking reports

COVID testing must be rigorous and multi-faceted for high-risk individuals. Photo Credit: Shutterstock

The researchers focused on the reverse transcriptase polymerase chain reaction (RT-PCR), the test most commonly used for high-risk people. Previous use of this test has shown that can produce false negative in early stages, particularly when the tested sample does not contain sufficient presence of the virus. The researchers analyzed 7 previously published studies on RT-PCR performance.

In all, the studies covered 1,330 respiratory swab samples from outpatients and inpatients with SARS-CoV-2 infection. They found that during the first four days of the infection, before the onset of the symptoms, the probability of a false-negative result decreases from 100 percent (day 1) to 67 percent (day 4). The probability further keeps dropping as the infection progresses till day 9 when it again starts climbing.

The results indicate that false negative for the SARS-COV-2 virus is high during the first four days of the infection. This means that we must re-evaluate early test result interpretations and monitoring among high-risk individuals. RT-PCR cannot be the sole testing mechanism where clinical suspicion is high, concluded the researchers.

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About the Author

Paromita Datta covers the latest health and wellness trends for Organic Facts. An ex-journalist who specialized in health and entertainment news, Paromita was responsible for managing a health supplement for The New Indian Express, a leading national daily in India. She has completed her post-graduation in Business Administration from the University of Rajasthan and her diploma in journalism from YMCA, Delhi. She has completed an e-course, Introduction to Food and Health, from Stanford University, US.

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