Diosmin Uses & Side Effects

by John Staughton (BASc, BFA) last updated -

Diosmin is commonly turned to by people suffering from vascular problems, as they have often found relief from this natural remedy. 

What is Diosmin?

Diosmin is categorized as a flavonoid, which is the part of the pigments of fruits and vegetables that are responsible for their vivid and appetizing colors. This compound is found mainly in citrus fruits. It is extracted and used to make medicine that can treat a number of inflammatory conditions. [1]

What Can Diosmin Treat?

There is promising evidence that this flavonoid supplement, when taken in combination with another flavonoid, hesperidin, can help the following conditions:

A variety of sliced citrus fruits on a surface

Citrus Fruits are the great source of Vitamin C and also used to treat common cold. Photo Credit: Shutterstock

Leg Ulcers

Citrus flavonoids prescribed by a doctor were shown to reduce inflammation in the leg veins of people suffering from leg ulcers. By reducing inflammation, veins were able to heal and there was less loss of fluid into the legs. When combined with compression (medical socks, tights, or wrapping), diosmin and hesperidin greatly reduced the presence of leg ulcers and can relieve discomfort for the many people suffering from this common issue.  [2]


The anti-inflammatory properties of diosmin and hesperidin, along with their ability to improve vascular quality, are what make it an excellent treatment for hemorrhoids. A supplement or prescription is taken orally has shown great improvement in people dealing with this affliction. [3]

Diosmin is also used by some people to prevent liver damage, treat varicose veins, or lessen lower back pain. It is even suspected to help treat bleeding of the gums or eyes. Its effectiveness for treating these conditions has not been well documented and is considered circumstantial at this time, but anecdotal evidence exists in many forms. 

How to Take Diosmin?

This specialty flavonoid is available in prescription form and has been approved by the FDA as a ‘medical food’. You can find supplements in specialty stores or online, but always consult your doctor before beginning any natural health care routine.

Side Effects of Diosmin

Some people have reported an upset stomach or abdominal pain, while others experienced skin rash or hives. These are not terribly common and diosmin is considered safe for most healthy people. Research with lab animals showed minimal to no side effects. People with blood disorders or heart conditions should know that this supplement can cause an increased heart rate. [4]

As with any natural remedy, you should consult your doctor and tell them about any medications you are taking before adding a supplement to your daily routine. Always buy supplements from a trusted source and stop taking them if you notice any uncomfortable side effects.

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About the Author

John Staughton is a traveling writer, editor, publisher and photographer with English and Integrative Biology degrees from the University of Illinois in Champaign-Urbana (USA). He co-founded the literary journal, Sheriff Nottingham, and now serves as the Content Director for Stain’d Arts, a non-profit based in Denver, Colorado. On a perpetual journey towards the idea of home, he uses words to educate, inspire, uplift and evolve.

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