Top Lithium Orotate Benefits & Side Effects

by John Staughton (BASc, BFA) last updated -

Lithium orotate isn’t the most common supplement and is typically only recommended for certain conditions or deficiencies, but it does have certain benefits for your overall health.

What is Lithium Orotate?

Lithium orotate is a compound derived from lithium that can be bought over the counter in most pharmacies and stores. It is a salt, composed of lithium, an alkali metal, and orotic acid, which is also produced naturally in the body.

While lithium and lithium carbonate are approved medications for a variety of disorders, lithium orotate is marketed as a dietary supplement and is therefore not approved by the FDA for any medical treatment. However, proponents claim that it has some of the same neuroprotective effects as regular lithium, despite the doses being much lower. They also claim that it easily passes through the blood-brain barrier, much more so than other lithium forms. [1]

Lithium orotate is primarily used for mood stabilization, the treatment of psychiatric disorders, and some physical ailments. When taking lithium, it is important to be careful about dosage, as too much lithium can be toxic.

Epsom salt in a rustic wooden bowl against a wood background

Lithium orotate is a salt of orotic acid and lithium. Photo Credit: Shutterstock

Lithium Orotate Benefits

Lithium orotate has the ability to potentially improve cognitive function, enhance mood, and increase bone strength. It has also been known to be used to manage depression, mental health issues, and alcoholism. Let us look at the benefits in detail.

Cognitive Function

Lithium has been found to help encourage the growth of new neurons, and prevent damage to existing ones from stress-induced cortisol. It was found to stimulate neurogenesis in animals with Down’s Syndrome, and strengthens the signals between neurons, helping boost communication between different parts of the brain. Lithium also helps increase N-acetyl aspartate (NAA), which has been linked to higher IQ scores and is a neuroprotective amino acid. [2]

Psychiatric Benefits

Lithium has many different applications in psychiatry, from ADHD to obsessive-compulsive disorder. It increases sensitivity to serotonin. Lithium may also help regulate dopamine levels in the brain, which can help people diagnosed with obsessive-compulsive disorder, or who have gambling addictions.

People with anorexia and other eating disorders have also had some success with lithium supplementation.


Lithium orotate is a popular supplement for people going through withdrawal [4]or those who are recovering from alcoholism. Furthermore, people using lithium report far less frequency of relapse in the first 18 months after quitting.

Bone Health 

Lithium may help prevent bone degeneration, increasing bone strength and reducing the risk for fractures. In an Iranian study [5] from 2009, researchers found that patients receiving lithium supplementation had lower bone cell turnover and higher bone densities.


Small doses of lithium orotate may actually help you live longer. Lithium improves mitochondrial function, increasing cellular energy output and encouraging damaged mitochondria to be recycled. Higher lithium amounts in drinking water have been linked to longer lifespans versus people who have lower lithium levels, and studies on roundworms have shown promising [6] correlations.


Lithium stimulates a process called autophagy, wherein cells recycle themselves and reuse the raw materials. This can be considered helpful [7]when it comes to neurodegenerative diseases like Alzheimer’s and Parkinson’s, as recycling damaged proteins can stimulate healthy cell growth. In animal studies, lithium prevented nerve cell death in subjects with Huntington’s Disease and reduced excessive NMDA receptor function. It has also been shown to reduce the symptoms of Tourette’s, and reduce involuntary spastic body tics.

Other Benefits

Lithium orotate is thought to be an effective help for cluster and migraine headaches. It is being studied for its power to stimulate white blood cell production in people with autoimmune diseases. Taking lithium orotate with calcium may help treat symptoms of hepatitis. Finally, while it remains unverified scientifically, many people believe that low levels of lithium can also reduce epileptic seizures.

Side Effects of Lithium Orotate

There are many side effects that people experience when taking lithium, although lithium orotate contains much lower doses than prescribed lithium. Slight lithium toxicity, from small doses, can manifest as tremors, weakness, fatigue, headaches, vomiting, and diarrhea. Mid-level lithium poisoning can manifest as confusion, twitching, and problems speaking.

Severe toxicity can result in coma, seizures, kidney damage, and even death. Lithium may interfere with thyroid function, inhibit the absorption of magnesium by the body, and can cause intestinal irritation. It is not recommended for anyone with kidney or liver issues, Crohn’s disease, or any woman pregnant or nursing. Considering the uncertainty regarding dosage and overall safety of lithium supplements, it is best to speak with a doctor before using this compound, particularly if you are already on any prescribed medications. Protection Status
About the Author

John Staughton is a traveling writer, editor, publisher and photographer with English and Integrative Biology degrees from the University of Illinois in Champaign-Urbana (USA). He co-founded the literary journal, Sheriff Nottingham, and now serves as the Content Director for Stain’d Arts, a non-profit based in Denver, Colorado. On a perpetual journey towards the idea of home, he uses words to educate, inspire, uplift and evolve.

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