6 Amazing Benefits of Nattokinase

by John Staughton (BASc, BFA) last updated -

Nattokinase can have a very powerful effect on cardiovascular health, but also has a notable impact on other areas of the body.

What is Nattokinase?

Nattokinase is an enzyme that is produced and extracted from a traditional Japanese food called natto, which is composed of fermented soybeans. When you consume nattokinase, it begins to break down certain proteins within the body and various organ systems, along with different blood clots and cellular toxins, thus improving metabolism and boosting the body’s efficiency.

This specific enzyme is known as a protease and plays an important part in breaking down proteins in the body, as well as an arterial plaque in the cardiovascular system. It is closely related to serrapeptase, another proteolytic enzyme that performs many of the same functions. Generally speaking, nattokinase is very good for the body, although it is not considered an essential nutrient, by any means. [1]

A close-up shot of nattokinase

Nattokinase promotes normal blood flow, circulation, & maintains normal ranged blood pressure. Photo Credit: Shutterstock

Consuming this in food sources, as well as in supplement form, is becoming increasingly popular for its potential impact on critical aspects of health.

Nattokinase Benefits

The top benefits of nattokinase include the following:

  • Regulate blood pressure
  • Boost gastrointestinal health
  • Eliminate blood clots
  • Improve cardiovascular health

Let us discuss them in detail below.

Gastrointestinal Tract

Enzymes are critical parts of the digestive system, and in the case of nattokinase, it can help to stabilize and normalize your digestive processes, thus eliminating symptoms of diarrhea, bloating, and cramping. [2]

Blood Pressure

By reducing the stickiness of arterial plaque, this enzyme is able to lower your risk of hypertension by clearing the way for easy blood flow through the blood vessels and arteries. [3]

Blood Clots

Nattokinase reduces that buildup and thus lowers the risk of blood clots getting stuck.


When your blood is flowing unobstructed, there is far more oxygenation of your organ systems taking place, as well as the delivery of different resources to key parts of the body, improving your overall metabolism and health. [4]

Neurodegenerative Disease

According to an animal study published in Human and Experimental Toxicology journal, nattokinase showed potential in lowering the levels of amyloid plaque in the brain. However, more research is required to establish the same. [5]

Nattokinase Side Effects

There are a number of nattokinase side effects of which you should be aware, particularly if you are taking concentrated supplements of this enzyme, including bleeding disorders, as well as complications with surgery, pregnancy, and liver issues.

  • Blood Clotting: This enzyme is known to reduce blood clotting in the body, which can cause additional bleeding disorders, as well as complications during surgery. If you are taking blood-clotting medication, avoid consuming additional nattokinase.
  • Pregnancy: There is limited knowledge about the effects of this enzyme on pregnant and nursing women, so it is generally recommended to avoid these supplements or the consumption of natto.
  • Liver Problems: Some anecdotal evidence points to this enzyme exacerbating liver problems when taken regularly, so consult with a doctor before adding natto or enzyme supplements to your diet.
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About the Author

John Staughton is a traveling writer, editor, publisher and photographer with English and Integrative Biology degrees from the University of Illinois in Champaign-Urbana (USA). He co-founded the literary journal, Sheriff Nottingham, and now serves as the Content Director for Stain’d Arts, a non-profit based in Denver, Colorado. On a perpetual journey towards the idea of home, he uses words to educate, inspire, uplift and evolve.

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