One of the oldest remedies for blisters and skin ailments of all kinds is castor oil. This remedy is so effective because castor oil effectively smothers those skin cells, sucking out all the moisture and leaving dry, healthy skin behind. You can apply castor oil to your blister before going to bed at night, and in the morning, you will see a noticeable different. However, it is important that you not pick at the layer of skin that remains behind once the blister is reduced in size. Exposing the skin beneath may cause a new blister to form, and also opens you up to vulnerability from infection.